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Company

Crysforma - ICIQ

Street
Av Països Catalans
ZIP Code
43007
City
Tarragona
Country
Spain


Company Profile:
Crysforma provides complete scientific support for the discovery, analysis and scale-up of polymorphs, hydrates, amorphous phases, salts and co-crystals of active pharmaceutical ingredients or intermediates.

Crysforma is a technology development unit belonging to the Institute of Chemical research of Catalonia (ICIQ), located in Tarragona.
Profiltitel

Polymorphism screening services

What we offer:
Crysforma offers complete scientific support to discover and characterize the most relevant polymorphs, hydrates and amorphous phases of a drug and to select the candidate with optimal solid state properties.

Crysforma has developed its own crystallization screening methodology based in the use of several crystallization procedures, oriented to obtain the thermodynamically stable phase as well as kinetically favoured phases. Moreover, solvent-mediated as well as solvent-free crystallization procedures are assayed.

Type of studies:
■Initial or fast polymorphism screening for early stages candidates
■Comprehensive polymorphism study of a drug substance
■Determination of the relative stability of different polymorphs
■Scale-up of selected polymorphs
■Development of analytical methods for polymorph quantification
■Fast powder X-ray diffraction analysis characterization

What are we looking for:
We are looking for pharmaceutical companies (either originator or generic) or fine chemicals companies that are interested in outsourcing polymorphism screening projects, or need to solve problems in the general area of polymorphism or solid state development.

Keywords:
  • ] Agrochemicals
  • ] Organic substances
  • ] Pharmaceutics
  • ] Special Chemicals, intermediates
  • ] Analytical chemistry


Collaboration sought:
  • Research and development
  • Technical Co-operation


Responsible

Ms Irene Puntí

Business Development Manager

Profiltitel

Pharmaceutical Salt Selection

What we offer:
Crysforma offers systematic salt screening studies to discover and select the salt derivative of an API with optimal solid state properties.

Preparation of a salt is the classical strategy to optimize the solid state properties of an API. Salt derivatives can improve crystallinity, solubility and stability.

Crysforma has developed its own salt screening methodology based in the use of selected crystallization procedures in an optimized group of crystallization solvents. The methodology allows performing 1000 crystallization experiments from 10 g of starting API .

Type of studies:
■Salt screening of pharmaceutical ingredients with selected counterions
■Characterization of crystalline salts
■Development of reliable preparation procedures
■Scale-up of the selected salt

What are we looking for:
Pharmaceutical and fine chemicals companies interested in outsourcing salt screening projects or in that require scientific and technical assistance in the field of solid state development in general.

Keywords:
  • ] Agrochemicals
  • ] Organic substances
  • ] Pharmaceutics
  • ] Special Chemicals, intermediates
  • ] Analytical chemistry


Collaboration sought:
  • Research and development
  • Technical Co-operation


Responsible

Ms Irene Puntí

Business Development Manager

Profiltitel

Pharmaceutical Co-crystal screening

What we offer:
Systematic co-crystal screening studies to discover and select the co-crystal of an API with optimal solid state properties.

In recent years, the development of a pharmaceutical co-crystal has become a novel strategy to improve the solid state properties of an API as alternative to salts.

We have our own co-crystal screening methodology for co-crystal formers with very different solubilities, combining several crystallization procedures, as solid state grinding, solvent evaporation, reaction crystallization and crystallization from the melt.

Type of studies:
■Co-crystal screening of pharmaceutical ingredients with selected co-crystal formers
■Characterization of pharmaceutical co-crystals
■Development of reliable preparation procedures
■Scale-up of the selected co-crystal

What are we looking for:
Pharmaceutical and fine chemicals companies that rwant to outsource screening projects or require scientific and technical assistance in the field of solid state development of APIs and intermediates

Keywords:
  • ] Agrochemicals
  • ] Organic substances
  • ] Pharmaceutics
  • ] Analytical chemistry


Collaboration sought:
  • Research and development
  • Technical Co-operation


Responsible

Ms Irene Puntí

Business Development Manager

Profiltitel

Crsytallization of pharmaceutical compounds

What we offer:
Complex crystallization challenges related to crystallization of poorly crystalline compounds, crystallization scale-up, or optimization of crystallization processes to improve yield, purity or crystallinity and to obtain the desired polymorph controlling the particle size distribution to fulfil the industrial process needs.

Type of studies:
■Crystallization of compounds that are difficult to crystallize
■Development and scale-up of robust crystallization procedures
■Optimization of crystallization processes (yield, desired polymorph, purity, particle size, crystallinity, etc.)
■Crystallizations oriented to the generation of single crystals and SCXRD structure determination of pharmaceutical organic molecules and natural products, including absolute configuration determination

What are we looking for:
Pharmaceutical and fine chemicals companies that require support in crystallization of medium to small organic molecules or on any other aspect of solid state development of APIs and intermediates.

Keywords:
  • ] Agrochemicals
  • ] Organic substances
  • ] Pharmaceutics
  • ] Special Chemicals, intermediates
  • ] Analytical chemistry
  • ] Separation Technologies


Collaboration sought:
  • Research and development
  • Technical Co-operation


Responsible

Ms Irene Puntí

Business Development Manager

Profiltitel

Chiral resolution through formation of diastereomeric salts and chiral co-crystals

What we offer:
Crysforma has successfully applied its in-house developed salt and co-crystal screening methodology to the resolution of chiral molecules with ionization sites through diastereomeric salt formation. In a similar way, non-ionisable chiral molecules can also be resolved by formation of co-crystals with chiral coformers.

Type of studies:
■Crystallization screening to discover the optimal chiral resolution agent and crystallization solvent
■Scale-up of the resolution process.
■Development of HPLC analytical methods to determine the enantiomerical excess
■Determination of absolute configuration by single crystal X-ray diffraction of enantiomerically pure compounds

What are we looking for:
Pharmaceutical and fine chemicals companies

Keywords:
  • ] Agrochemicals
  • ] Organic substances
  • ] Pharmaceutics
  • ] Special Chemicals, intermediates
  • ] Analytical chemistry
  • ] Separation Technologies


Collaboration sought:
  • Research and development
  • Technical Co-operation


Responsible

Ms Irene Puntí

Business Development Manager

Profiltitel

Powder X-Ray Diffraction Services - Polymorph detection and quantification

What we offer:
POLYMORPH QUANTIFICATION AND DETECTION LIMIT QUANTIFICATION
Development of analytical methods for the quantification of a polymorph in a mixture and the determination of the limit of detection (LOD). We can quantify a polymorph and determine its presence with very low detection limits (typically in the range of 0.3 and 1%).

FAST ANALYSIS SERVICE
Fast and reliable powder X-Ray diffraction service, including:
■Crystalline phase identification, against standards defined by the company.
■Measurements according to analytical methods developed by Crysforma.
■Component search in databases.

VARIABLE TEMPERATURE PXRD
On its own or with other thermal analysis techniques, VT-PXRD can provide data on crystal structure, dehydration / desolvation, phase transitions, melting and decomposition.

What are we looking for:
Pharmaceutical and fine cehmical companies

Keywords:
  • ] Agrochemicals
  • ] Organic substances
  • ] Pharmaceutics
  • ] Special Chemicals, intermediates
  • ] Analytical chemistry


Collaboration sought:
  • Research and development
  • Technical Co-operation


Responsible

Ms Irene Puntí

Business Development Manager

Profiltitel

API and intermediate solubility studies

What we offer:
SOLUBILITY SCREENING
Information on the best solvent media for a given crystallization process. Solubility data is also relevant during pre-formulation evaluations of APIs. Solubility curves and metastable zone width in a given solvent are determined with small amount of API and in a short period of time.

INTRINSIC DISSOLUTION
An additional characterization of bulk drug substances and excipients is the measurement of intrinsic dissolution rates. Its determination can be in some cases important since bioavailability of an API is influenced by the dissolution rate. Furthermore, intrinsic dissolution tests are a way to prove chemical purity, batch-to-batch consistency and sameness after changes in production.

What are we looking for:
Pharmaceutical and fine chemical companies

Keywords:
  • ] Agrochemicals
  • ] Organic substances
  • ] Pharmaceutics
  • ] Analytical chemistry


Collaboration sought:
  • Research and development
  • Technical Co-operation


Responsible

Ms Irene Puntí

Business Development Manager

Profiltitel

Amorphous content determination in a crystalline solid

What we offer:
Mechanical stresses during processing may introduce small amounts of amorphous material which can have a relevant effect on the products properties, including solubility and stability. Crysforma applies several available analytical techniques (PXRD, thermal analysis, GVS) to determine small amounts of amorphous phase in a crystalline solid.

What are we looking for:
Pharmaceutical and fine chemical companies

Keywords:
  • ] Agrochemicals
  • ] Organic substances
  • ] Pharmaceutics
  • ] Analytical chemistry


Collaboration sought:
  • Research and development
  • Technical Co-operation


Responsible

Ms Irene Puntí

Business Development Manager

Profiltitel

API Solid form hygroscopicity and stability

What we offer:
Use of gravimetric vapour sorption (GVS) and climatic chambers to determine the effects of relative humidity and temperature on the solid form of interest.

What are we looking for:
Pharmaceutical and fine chemicals companies

Keywords:
  • ] Agrochemicals
  • ] Organic substances
  • ] Pharmaceutics
  • ] Analytical chemistry


Collaboration sought:
  • Research and development
  • Technical Co-operation


Responsible

Ms Irene Puntí

Business Development Manager

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