Synthesis of dendritic systems of nanoscopic size for applications in biomedicine.
What we offer:
BIOINDEN research group, from the Inorganic Chemistry Department of Alcalá University has develop a technology consisting in the synthesis and structural characterization of dendritic systems of nanoscopic size with applications in different fields of biomedicine. Among all of them, the group launches the development of these systems for the transport and release of drugs as a vehicle of transfection in gene therapy or as therapeutic agents (antibacterial, antiviral or antiprionics).
Regarding the cationic systems developed, the principal innovative aspects are the following:
- They are non viral nanoscopic synthetic molecules able to internalise nuclear material inside different cellular lines. This turns them into good candidates to be considered as non viral vectors in gene therapy processes.
- They are non toxic in a concentration range adapted for the accomplishment of different biomedical studies.
- They present antibacterial properties against gram + and gram- bacteria
- They are able of interacting, in a electrostatic way, with anionic drugs which turns them into drug delivery systems.
- They present a hydrophobic carbosilane skeleton that allows the molecules to cross the cellular membranes with major facility.
- They are soluble in water.
Regarding the anionic systems developed, the principal innovative aspects are the following:
- They have an important antiviral capacity
- They are able to inhibit the infection for HIV
- They have antiinflammatory capacity
- They are good candidates for the production of a microbicide gel of topic use that prevents the infection of the virus across sexual transmission.
What are we looking for:
The research group is looking for joint venture agreements or licensing agreements with companies from the chemistry, pharma or biotechnology sector.
Patent granted with reference P200501810
- ] Organic substances
- ] Pharmaceutics
- ] Micro- and Nanotechnology
- Joint Venture Agreement
- Licence Agreement